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  • Title: Synthesis and antibacterial evaluation of novel pleuromutilin derivatives.
    Author: Shang R, Liu Y, Xin Z, Guo W, Guo Z, Hao B, Jianping L.
    Journal: Eur J Med Chem; 2013 May; 63():231-8. PubMed ID: 23501109.
    Abstract:
    A series of novel pleuromutilin derivatives possessing thioether moiety has been synthesized via acylation reaction under mild conditions. Their in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Escherichia coli, and Streptococcus agalactiae were tested by agar dilution method and Oxford cup assay. Among the 17 compounds screened, 14-O-[(4-methoxybenzamide-2- methylpropane-2-yl) thioacetate] mutilin 4i, 14-O-[(2-aminobenzamide-2-methylpropane-2-yl) thioacetate] mutilin 5a and 14-O-[(4-aminobenzamide-2-methylpropane-2-yl) thioacetate] mutilin 5c were resulted as most active antibacterial agents.
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