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  • Title: Hypertonic (3%) saline vs 0.93% saline nebulization for acute viral bronchiolitis: a randomized controlled trial.
    Author: Sharma BS, Gupta MK, Rafik SP.
    Journal: Indian Pediatr; 2013 Aug; 50(8):743-7. PubMed ID: 23502662.
    Abstract:
    OBJECTIVE: To compare the length of hospital stay (primary) and improvement in clinical severity scores (secondary) among children with bronchiolitis nebulized with 3 % hypertonic saline or 0.9% saline. DESIGN: Randomized double blind controlled trial. SETTINGS: Tertiary care teaching hospital. PATIENTS: Hospitalized children (1-24 months) with acute bronchiolitis of moderate severity. INTERVENTION: Nebulization of 4 ml of 3% hypertonic saline or 4 mL of 0.9% saline, along with 2.5 mg salbutamol, at 4-hourly intervals till the patient was ready for discharge. RESULTS: Baseline characteristics were similar in two groups. Median clinical severity score at admission was 6 (IQR-1) in both the groups. Clinical severity scores monitored afterwards 12-hourly till discharge (132 h) did not show statistically significant differences in 3% and 0.9% saline groups. Mean length of hospital stay (time to reach predefined clinical severity score<3) was 63.93 ± 22.43 h in 3% saline group and 63.51 ± 21.27 h in 0.9% saline group (P=0.878). No adverse events were reported by the parents, caregivers or treating medical attendants in both groups. CONCLUSION: Nebulized 3 % saline is not superior to 0.9% saline in infants with clinically diagnosed acute bronchiolitis.
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