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  • Title: The circadian binding of CLOCK protein to the promoter of C/ebpα gene in mouse cells.
    Author: Kawasaki H, Doi R, Ito K, Shimoda M, Ishida N.
    Journal: PLoS One; 2013; 8(3):e58221. PubMed ID: 23505471.
    Abstract:
    C/EBPα plays important roles in metabolism as well as in the maintenance of energy homeostasis. Here we describe loss of the circadian oscillation of C/ebpα expression in liver of Clock mutant mice. Reporter assays indicate Clock and Bmal significantly induced C/ebpα gene expression whereas Cry suppressed. Real time reporter assays showed that two mutated E-boxes disrupted C/ebpα promoter dependent-oscillation. Chromatin immunoprecipitation suggests Clock can bind to two E-boxes in the C/ebpα promoter with a circadian manner in vivo. Thus, C/ebpα gene transcription is under circadian control of a core clock component, Clock. The data suggests that circadian disturbances may affect metabolic abnormalities through the C/ebpα pathway in liver.
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