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  • Title: CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides.
    Author: Westermann B, Dörner S, Brauch S, Schaks A, Heinke R, Stark S, van Delft FL, van Berkel SS.
    Journal: Carbohydr Res; 2013 Apr 19; 371():61-7. PubMed ID: 23507494.
    Abstract:
    Di- and triguanidinylation of trehalose, sucrose, and melizitose has been achieved via a Huisgen-cycloaddition approach. They can serve as aminoglycoside-arginine conjugate mimics, which has been demonstrated by their biological profiles in assays against Bacillus subtilis. For comparative studies, tetraguanidinylated neamine and kanamycin derivatives have also been synthesized and evaluated.
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