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  • Title: [Evaluation of the inflammatory process in hepatic disorders: immunochemistry of C alpha-reactive protein and of alpha 1-acid glycoprotein].
    Author: Monnet D, Kokora G, Cisse M, Ferly-Therizol M, Moreau J, Durand G, Lonsdorfer A, Yapo AE.
    Journal: Bull Soc Pathol Exot; 1990; 83(1):107-13. PubMed ID: 2350838.
    Abstract:
    C-reactive protein (CRP) and alpha 1-acid glycoprotein (alpha 1-GPA) two acute phase reactants, have both been monitored in patients suffering from hepatocellular diseases, compared with healthy subjects. Immunochemical findings, in hepatic amebiasis, revealed a higher incidence of increased alpha 1-GPA levels (86% of patients, as compared to 46% for CRP), whereas during liver primitive cancer and cirrhosis inverse pattern occurs. In viral chronic hepatitis, lesser perturbations were observed. In contrast, a simultaneous increase of both proteins is strong supporting evidence for the severity of disease with an unfavourable prognostic.
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