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  • Title: Serum eosinophil cationic protein levels in Behçet's disease and its relation to clinical activity.
    Author: Tas DA, Ozer HT, Erken E.
    Journal: Asian Pac J Allergy Immunol; 2013 Mar; 31(1):67-72. PubMed ID: 23517396.
    Abstract:
    BACKGROUND: Eosinophil cationic protein (ECP) is a matrix protein of eosinophils and has been reported to reflect eosinophil activity. Few studies have examined the role of eosinophils in the pathogenesis of Behçet's disease. OBJECTIVE: The purpose of the present study was to investigate the serum ECP levels in BD and its relation to clinical activity. METHODS: Forty-seven consecutive patients with BD (22 active, 25 inactive), 21 age and sex matched patients with allergic rhinitis and 21 healthy controls were evaluated cross-sectionally. The serum ECP levels were measured by the flourescein enzyme immunoassay method. RESULTS: Mean serum ECP levels of active patients with BD (34.28 ± 23.43 μg/L) were found to be significantly lower than those of the inactive patients (65.69 ± 46.32 μg/L, p <0.05) and the controls (62.92 ± 30.49 μg/L, p <0.01) . Behçet patients with oral aphthous lesions had significantly lower mean serum ECP levels (n=21, 38.82 ± 33.38 μg/L) than those without aphthous lesions (n=26, 60.81 ± 43.21μg/L) (p = 0.041). Similarly patients with arthritis had lower serum ECP values (n=6, 22.12 ± 9.47 μg/L) than those without arthritis (n = 41, 55.21 ± 41.35 μg/L) (p =0.029). CONCLUSIONS: Lower ECP levels in the active phase of the disease may be a result of decreased production due to the activation of Th1 cytokines.
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