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  • Title: Eosinophil recruitment to nasal nerves after allergen challenge in allergic rhinitis.
    Author: Thornton MA, Akasheh N, Walsh MT, Moloney M, Sheahan PO, Smyth CM, Walsh RM, Morgan RM, Curran DR, Walsh MT, Gleich GJ, Costello RW.
    Journal: Clin Immunol; 2013 Apr; 147(1):50-57. PubMed ID: 23518598.
    Abstract:
    In allergen challenged animal models, eosinophils localize to airway nerves leading to vagally-mediated hyperreactivity. We hypothesized that in allergic rhinitis eosinophils recruited to nasal nerves resulted in neural hyperreactivity. Patients with persistent allergic rhinitis (n=12), seasonal allergic rhinitis (n=7) and controls (n=10) were studied. Inferior nasal turbinate biopsies were obtained before, 8 and 48h after allergen challenge. Eight hours after allergen challenge eosinophils localized to nerves in both rhinitis groups; this was sustained through 48h. Bradykinin challenge, with secretion collection on the contralateral side, was performed to demonstrate nasal nerve reflexes. Twenty fourhours after allergen challenge, bradykinin induced a significant increase in secretions, indicating nasal hyperreactivity. Histological studies showed that nasal nerves expressed both vascular cell adhesion molecule-1 (VCAM-1) and chemokine (C-C motif) ligand 26 (CCL-26). Hence, after allergen challenge eosinophils are recruited and retained at nerves and so may be a mechanism for neural hyperreactivity.
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