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  • Title: PIK3C3/VPS34, the class III PtdIns 3-kinase, plays indispensable roles in the podocyte.
    Author: Chen JK.
    Journal: Autophagy; 2013 Jun 01; 9(6):923-4. PubMed ID: 23518611.
    Abstract:
    The mammalian homolog of yeast Vps34 (PIK3C3/VPS34) is implicated in the regulation of autophagy, and recent studies have suggested that autophagy is a key mechanism in maintaining the integrity of renal glomerular podocytes. To date, however, the role of PIK3C3 in podocytes has remained unknown. We generated a line of podocyte-specific Pik3c3-knockout (Pik3c3 (pdKO) /mVps34 (pdKO) ) mice and demonstrated an indispensable role for PIK3C3 in the regulation of intracellular vesicle trafficking and processing to protect the normal cellular metabolism, structure and function of podocytes.
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