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  • Title: Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity.
    Author: Darandale SN, Pansare DN, Mulla NA, Shinde DB.
    Journal: Bioorg Med Chem Lett; 2013 May 01; 23(9):2632-5. PubMed ID: 23522562.
    Abstract:
    It is the first report of 1,3,4,5-tetrasubstituted 1,2,3,6-tetrahydropyrimidines derivatives, catalyzed by ZrOCl2. The mild reaction conditions, excellent yields in shorter reaction time and evasion of cumbersome workup procedures make this process economically lucrative for industrial application. The novelty and highlight of the present method is the promising antibacterial and antifungal activity shown by compounds (4a, 4b, 4e, 4f, 4h and 4l) compared to standard.
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