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  • Title: Preliminary X-ray crystallographic analysis of holotoxin from Bordetella pertussis.
    Author: Raghavan M, Gotto JW, Scott JV, Schutt CE.
    Journal: J Mol Biol; 1990 Jun 05; 213(3):411-4. PubMed ID: 2352276.
    Abstract:
    Pertussis (whooping cough) is a serious infectious disease caused by the bacterium Bordetella pertussis. One of the major virulence factors is a protein known as pertussis toxin, which is composed of six subunits, with a total molecular weight of 106,000. Enzymatic transfer of ADP-ribose from NAD to a family of GTP-binding proteins is effected by the largest subunit (S1 or the A monomer), while binding of host cells and entry of S1 to the interior is a function of the other subunits (the B oligomer). The holotoxin crystallizes in the orthorhombic space group P2(1)2(1)2(1), with unit cell dimensions a = 98.4 A, b = 164.2 A and c = 195.2 A. The crystals are suitable for high-resolution X-ray diffraction analysis.
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