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  • Title: [Development of sarcoidosis during treatment for chronic hepatitis C with pegylated interferon alfa-2a and ribavirin: case report and literature review].
    Author: Cacopardo B, Pinzone MR, Nunnari G.
    Journal: Infez Med; 2013 Mar; 21(1):40-44. PubMed ID: 23524900.
    Abstract:
    Sarcoidosis is a chronic inflammatory multisystem disease of unknown aetiology. IFN-alfa is an immunomodulatory cytokine, currently used with ribavirin in the treatment of chronic hepatitis C infection. Due to its effects on the immune system, IFN-? may lead to the induction or exacerbation of autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and sarcoidosis. We report on a 37-year-old man, presenting with sarcoidosis during a six-month course of PEG-IFN alfa-2a and ribavirin for chronic hepatitis C virus genotype 3 infection.
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