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  • Title: Derivatization in liquid chromatography for mass spectrometric detection.
    Author: Santa T.
    Journal: Drug Discov Ther; 2013 Feb; 7(1):9-17. PubMed ID: 23524938.
    Abstract:
    Liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) has been frequently utilized for the sensitive and selective determination of the trace level compounds in biological samples. In LC/ESI-MS/MS, chemical derivatization is sometimes used to enhance the detection sensitivity of the analytes. This review presents an overview of the derivatization reagents in LC/ESI-MS/MS that have been applied to the low molecular weight compounds in recent five years (2008-2012).
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