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  • Title: Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors.
    Author: Wieberneit F, Korste A, Albada HB, Metzler-Nolte N, Stoll R.
    Journal: Dalton Trans; 2013 Jul 21; 42(27):9799-802. PubMed ID: 23525213.
    Abstract:
    Binding of Leu-enkephalin and [Rh(III)(η(5)-Cp*)(η(6)-Tyr(1))]Leu-enkephalin to the recently published crystal structures of the μ- and δ-opioid receptor is studied. Docking of free Leu-enkephalin reveals two preferred conformations, one of which suggests an alternative binding site for the tyrosine residue. Furthermore, the three-dimensional solution structure of [Rh(III)(η(5)-Cp*)(η(6)-Tyr(1))]Leu-enkephalin was solved by using 2D NMR spectroscopic techniques.
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