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  • Title: A magnetically separable biocatalyst for resolution of racemic naproxen methyl ester.
    Author: Ozyilmaz E, Sayin S.
    Journal: Bioprocess Biosyst Eng; 2013 Nov; 36(11):1803-6. PubMed ID: 23525833.
    Abstract:
    Candida rugosa lipase (CRL) was encapsulated via the sol-gel method, using 5, 11, 17, 23-tetra-tert-butyl-25,27-bis(2-aminopyridine)carbonylmethoxy-26, 28-dihydroxy-calix[4]arene-grafted magnetic Fe3O4 nanoparticles (Calix-M-E). The catalytic activity of encapsulated lipase (Calix-M-E) was tested both in the hydrolysis of p-nitrophenyl palmitate (p-NPP) and the enantioselective hydrolysis of racemic naproxen methyl ester. The present study demonstrated that the calixarene-based compound has the potential to enhance both reaction rate and enantioselectivity of the lipase-catalyzed hydrolysis of racemic naproxen methyl ester. The encapsulated lipase (Calix-M-E) had great catalytic activity and enantioselectivity (E > 400), as well as remarkable reusability as compared to the encapsulated lipase without supports (E = 137) for S-Naproxen.
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