These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Mei-p26 cooperates with Bam, Bgcn and Sxl to promote early germline development in the Drosophila ovary.
    Author: Li Y, Zhang Q, Carreira-Rosario A, Maines JZ, McKearin DM, Buszczak M.
    Journal: PLoS One; 2013; 8(3):e58301. PubMed ID: 23526974.
    Abstract:
    In the Drosophila female germline, spatially and temporally specific translation of mRNAs governs both stem cell maintenance and the differentiation of their progeny. However, the mechanisms that control and coordinate different modes of translational repression within this lineage remain incompletely understood. Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation of nanos mRNA. Together with recently published studies, these data suggest that Mei-P26 mediates both GSC self-renewal and germline differentiation through distinct modes of translational repression depending on the presence of Bam.
    [Abstract] [Full Text] [Related] [New Search]