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  • Title: [Ultrastructural changes in the hemato-encephalic barrier of adult animals after acute hypoxic hypoxia].
    Author: Konorova IL, Gannushkina IV.
    Journal: Patol Fiziol Eksp Ter; 1990; (1):37-9. PubMed ID: 2352780.
    Abstract:
    The ultrastructure of the blood-brain barrier (BBB) was studied in different periods after the effect of acute hypoxic hypoxia. Local changes in the BBB ultrastructure indicating increased transport of blood plasma through certain areas of the vascular wall were seen already 24 hours after the hypoxia session. Four days later these changes were more marked and more diffuse. In 7 days the ultrastructure of the vessels and the surrounding brain tissue showed more significant changes. In later periods a tendency towards restoration of the BBB ultrastructure was revealed, which was also irregular in its course. The greater or lesser vulnerability of the different regions of the brain vessels may be determined both by the uneven decrease of their tonus and by the possible differences in the metabolic changes in the different areas of the brain vascular system under such conditions.
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