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  • Title: tert-Butyl hydroperoxide-induced injury in isolated rat hepatocytes: a model for studying anti-hepatotoxic crude drugs.
    Author: Joyeux M, Rolland A, Fleurentin J, Mortier F, Dorfman P.
    Journal: Planta Med; 1990 Apr; 56(2):171-4. PubMed ID: 2353064.
    Abstract:
    Tert-butyl hydroperoxide induces in freshly isolated rat hepatocytes malonaldehyde formation and lacticodehydrogenase and aspartate amino-transferase leakage. This model, when adapted to crude extracts, permits the demonstration of both anti-lipoperoxidant and antihepatotoxic activity of reference products like quercetin and silymarin and plant extracts like Rosmarinus officinalis and Eschscholzia californica.
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