These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Comparison of brachial artery vascular responses among postmenopausal women receiving different doses of tibolone.
    Author: Carranza-Lira S, Cirigo-Hernández B, Sandoval-Barragán MP, Ramos-León JC.
    Journal: Int J Gynaecol Obstet; 2013 Jul; 122(1):75-7. PubMed ID: 23531438.
    Abstract:
    OBJECTIVE: To compare the effects of low and conventional doses of tibolone in brachial artery flux parameters among postmenopausal women. METHODS: Between March 2011 and September 2012, 24 postmenopausal women attending Gynecology and Obstetrics Hospital Luis Castelazo Ayala, Mexico City, for hormone replacement therapy were consecutively recruited. The women were alternately assigned to receive a daily dose of either 2.5mg (n=11) or 1.25mg (n=13) of oral tibolone. Before and after treatment, all women underwent a brachial artery Doppler ultrasound. The arterial diameter was measured, and the pulsatility index (PI) and the resistance index (RI) were calculated. A hyperemic stimulus was then induced and these parameters were measured again. RESULTS: Among the 24 women, the time since menopause ranged from 16 to 24 months, and the median treatment duration was 3 months. Both groups showed a significant increase in arterial diameter after treatment. There was no significant difference between the groups in arterial diameter, PI, and RI. The arterial diameter after hyperemic stimulus was significantly lower after treatment than before treatment in both groups. CONCLUSION: Low and conventional doses of tibolone induced similar changes in brachial artery flux parameters among postmenopausal women.
    [Abstract] [Full Text] [Related] [New Search]