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  • Title: Structure analysis of the La Guajira-Colombia population: a genetic, demographic and genealogical overview.
    Author: Rojas MY, Alonso LA, Sarmiento VA, Eljach LY, Usaquén W.
    Journal: Ann Hum Biol; 2013 Mar; 40(2):119-31. PubMed ID: 23534984.
    Abstract:
    BACKGROUND: This study examined whether cultural factors, as compared to geographical distance, have produced a population sub-structure among different groups from the La Guajira population (Amerindian Wayúu and other resident groups) that co-exist within the same region. AIMS: The aims of this study were to analyse this population to discover whether cultural barriers result in the sub-structure, to evaluate whether there is a genetic drift effect and to describe migration dynamics using a genetic, genealogical and demographic approach. SUBJECTS: This study examined a sample of 290 individuals who were grouped based on a genealogical criterion to distinguish between native individuals and migrants. MATERIALS AND METHODS: Using demographic information, the age and gender structure of the population and genetic drift estimators were analysed. Using 15 autosomal microsatellites, heterozygosity, Hardy-Weinberg equilibrium (HWE), inbreeding, sub-structure, recent migration rate and genetic relationships were also evaluated using a Principal Component analysis (PCA) using reference populations. RESULTS: La Guajira is a young population that is growing and exposed to a moderate effect of genetic drift (Neme 11.903). The Wayúu are highly diverse (Ho 0.727) and different from other groups, with the exception of Wayúu-Guajiro. This trend was also observed in other Amerindian populations. CONCLUSION: This study found a high level of admixture and gene flow within the Wayúu population despite cultural differences. Thus, although the Wayúu population differs from other population groups, it is not an isolated population.
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