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  • Title: Studies on the relationship between the equilibrium curve of oxyhemoglobin and 2,3-diphosphoglycerate in open-heart surgery.
    Author: Glynn MF, Cornhill F.
    Journal: Can J Surg; 1975 Jan; 18(1):73-6. PubMed ID: 235363.
    Abstract:
    The relationship between decreased oxygen affinity of hemoglobin and intraerythrocyte 2,3-diphosphoglycerate (2,3 DPG) concentration was confirmed and its existence during the period of open-heart surgery was demonstrated. It is suggested that the trauma sustained by the erythrocytes during their extracorporeal circulation is responsible, in large measure, for the decrease in 2,3 DPG concentration.
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