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  • Title: [Application and value of mutation detection in diagnosis and treatment of gastrointestinal stromal tumor].
    Author: Cao H, Wang M.
    Journal: Zhonghua Wei Chang Wai Ke Za Zhi; 2013 Mar; 16(3):208-11. PubMed ID: 23536336.
    Abstract:
    Mutation of c-kit and platelet-derived growth factor receptor alpha (PDGFRA) is the most important molecular feature of gastrointestinal stromal tumor (GIST). Mutation detection of these two genes is of great significance when establishing the diagnosis of a kit-negative GIST, or when predicting response to tyrosine kinase inhibitor. Furthermore, more and more researches focus on the feasibility of the mutation status using as a prognostic factor in recent years.
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