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  • Title: Polyunsaturated fatty acid-derived chromones exhibiting potent antioxidant activity.
    Author: Mohamed YM, Vik A, Hofer T, Andersen JH, Hansen TV.
    Journal: Chem Phys Lipids; 2013; 170-171():41-5. PubMed ID: 23541667.
    Abstract:
    The marine polyunsaturated lipid-derived natural product all-(Z)-5,7-dihydroxy-2-(4Z,7Z,10Z,13Z,16Z-nonadecapentaenyl) (1) and four analogs 5-8 have been synthesized and evaluated as antioxidants in two cell-based assays. The natural product 1 and the analog 5 exhibited interesting antioxidant effects with IC50-values of 14±9 and 29±3μM, respectively, in a cellular lipid peroxidation antioxidant activity assay using HepG2 cells. Moreover, in the HepG2 cellular antioxidant activity assay, the natural product 1 exhibited strong protective effects against reactive oxygen species with an IC50=160±25μM.
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