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  • Title: Evidence for a dipeptide porter in the lysosome membrane.
    Author: Bird SJ, Lloyd JB.
    Journal: Biochim Biophys Acta; 1990 May 24; 1024(2):267-70. PubMed ID: 2354179.
    Abstract:
    Small neutral dipeptides such as Gly-Gly are known to cross the lysosome membrane rapidly. The mode of dipeptide translocation was studied, using an osmotic-protection method. Results with dipeptide analogues, such as omega-amino aliphatic acids and taurine, indicated that dipeptides do not cross the rat liver lysosome membrane by unassisted diffusion. Using seven pairs of dipeptide stereoisomers, the penetration of the L-isomer was always found to be much more rapid than that of the D-analogue. It is concluded that the lysosome membrane contains a porter that recognizes and transports L-dipeptides.
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