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  • Title: Association between miR-146a rs2910164 polymorphism and autoimmune diseases susceptibility: a meta-analysis.
    Author: Chen HF, Hu TT, Zheng XY, Li MQ, Luo MH, Yao YX, Chen Q, Yu SY.
    Journal: Gene; 2013 Jun 01; 521(2):259-64. PubMed ID: 23545308.
    Abstract:
    Published data on the rs2910164 in microRNA-146a (miR-146a) are shown to be associated with increased or decreased autoimmune diseases risk. To derive a more precise estimation of the relationship, we performed a meta-analysis to systematically summarize the possible. A meta-analysis including 11 studies with 3042 controls and 2197 cases was performed for genotypes CC (recessive effect), CC+CG (dominant effect) and C allele in fixed or random-effects models based on between-study heterogeneity. Overall, no significant association between miR-146a G/C rs2910164 polymorphism and autoimmune diseases risk was found in all genetic models when all studies were pooled into the meta-analysis. SLE (OR=0.99, 95% CI: 0.90-1.10), RA (OR=0.98, 95% CI: 0.85-1.14) did not yield statistical significance as for C allele pooled studies. In the subgroup analysis by ethnicity, still no significant association was detected in all genetic models. Our meta-analysis suggests that there is no association between miR-146a G/C rs2910164 polymorphism and the development of autoimmune diseases.
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