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  • Title: Can hepatocellular carcinoma (HCC) produce unconventional metastases? Four cases of extrahepatic HCC.
    Author: Piccirillo M, Granata V, Albino V, Palaia R, Setola SV, Petrillo A, Tatangelo F, Botti G, Foggia M, Izzo F.
    Journal: Tumori; 2013; 99(1):e19-23. PubMed ID: 23549015.
    Abstract:
    AIMS AND BACKGROUND: Extrahepatic spread of hepatocellular carcinoma (HCC) diagnosed during the clinical course of the disease is not frequent; however, with the prolonged survival of HCC patients, the incidence of extrahepatic metastases seems to be increasing. METHODS AND STUDY DESIGN: We present four unusual cases of extrahepatic metastasis from HCC: the first concerns a patient who underwent a liver transplantation for HCC with cirrhosis and three years later developed metastases in the lung and the left orbit; the second is that of a patient who developed an extraperitoneal pararectal metastasis; in the third case a large osteolytic lesion developed on the left iliac bone, and in the fourth case we found an isolated metastasis in the left mandible. RESULTS AND CONCLUSIONS: These cases offer important information related to the unusual biology of isolated metastases from HCC after successful treatment of the primary cancer.
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