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  • Title: Antacid-induced acute pancreatitis.
    Author: Nykamp D, Kraus EJ.
    Journal: Consult Pharm; 2013 Apr; 28(4):247-51. PubMed ID: 23552706.
    Abstract:
    OBJECTIVE: To report a case of acute pancreatitis associated with the administration of high doses of over-the-counter (OTC) antacids containing calcium carbonate. SETTING: An acute care 276-bed community hospital. CASE SUMMARY: In this case report, a 68-year-old male was admitted to the hospital for nausea, vomiting, and stomach pain. Patient reported taking 15-20 OTC calcium carbonate (4.5-6.0 g elemental calcium) tablets for four to five days prior to admission. Patient's calcium level upon admission was 18.5 mg/dL. Laboratory values of amylase and lipase peaked at 2,768 U/L and 7,091 U/L, respectively. An abdominal computed tomography confirmed acute pancreatitis. For a period of 45 days, treatment in the intensive care unit for acute pancreatitis and latter for necrotizing pancreatitis was conducted. CONCLUSION: This case study supports an association between hypercalcemia and pancreatitis in patients who take greater than recommended dosages of calcium-containing antacids. OTC antacids are popular, but can cause serious adverse events when not used as directed.
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