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  • Title: 7-T MRI of the spinal cord can detect lateral corticospinal tract abnormality in amyotrophic lateral sclerosis.
    Author: Cohen-Adad J, Zhao W, Keil B, Ratai EM, Triantafyllou C, Lawson R, Dheel C, Wald LL, Rosen BR, Cudkowicz M, Atassi N.
    Journal: Muscle Nerve; 2013 May; 47(5):760-2. PubMed ID: 23553571.
    Abstract:
    INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting lower and upper motor neurons. Degeneration of the lateral corticospinal tract (CST) is a key finding in ALS cervical spinal cord autopsies. We hypothesized that in vivo ultra-high-field MRI of the cervical spinal cord can detect abnormality in the CST. METHODS: A patient with ALS (disease duration 23 months) and a healthy control were scanned at 7-T MRI using a 19-channel coil. Multi-echo T2*-weighted imaging was performed in the spinal cord, covering C2-C6. Cross-sectional resolution was 0.37 × 0.37 mm(2). RESULTS: We detected clear signal hyperintensity in both segments of the lateral CST in the ALS patient, which was significant when compared with the normal control subject (P < 10(-7)). CONCLUSION: We believe there are potential benefits of 7-T MRI for increased sensitivity and spatial accuracy in characterizing pathology in the spinal cord.
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