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Title: [Biotinidase deficiency--a progressive metabolic disease in children with seizures and ataxia]. Author: Anger H, Lorenz K, Cobet G. Journal: Psychiatr Neurol Med Psychol (Leipz); 1990 Mar; 42(3):163-6. PubMed ID: 2356250. Abstract: Biotinidase deficiency is the primary biochemical defect in late-onset multiple carboxylase deficiency and an autosomal recessive disorder and characterized by seizures, ataxia, alopecia and skin rash. We describe a colorimetric semiquantitative method for screening for biotinidase activity from dried samples of whole blood spotted on filter papers. The administration of biotin to affected children can be a lifesaving procedure and can prevent irreversible neurologic damage.[Abstract] [Full Text] [Related] [New Search]