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  • Title: Effect of cyclophosphamide and morin-5'-sulfonic acid sodium salt, alone or in combination, on ADMA/DDAH pathway in rats.
    Author: Merwid-Ląd A, Trocha M, Chlebda-Sieragowska E, Sozański T, Magdalan J, Ksiądzyna D, Szuba A, Kopacz M, Kuźniar A, Nowak D, Pieśniewska M, Fereniec-Gołębiewska L, Szeląg A.
    Journal: Pharmacol Rep; 2013; 65(1):201-7. PubMed ID: 23563039.
    Abstract:
    BACKGROUND: The aim of the study was to evaluate the effect of cyclophosphamide (CPX) and morin-5'-sulfonic acid sodium salt (NaMSA) on plasma asymmetric dimethylarginine (ADMA) level and dimethylarginine dimethylaminohydrolase (DDAH) activity in rat liver. METHODS: The study was performed on Wistar rats receiving normal saline, CPX (15 mg/kg/day), NaMSA (100 mg/kg/day) or both CPX and NaMSA for 10 consecutive days. RESULTS: Significant decrease in ADMA level was found in all groups when compared to the control. DDAH activity in the liver was significantly higher in CX group compared to the control group. CONCLUSION: Obtained results of ADMA/DDAH pathway parameters require further research.
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