These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Beta-lactamase-producing Enterobacteriaceae in hospital effluents.
    Author: Korzeniewska E, Harnisz M.
    Journal: J Environ Manage; 2013 Jul 15; 123():1-7. PubMed ID: 23563146.
    Abstract:
    Beta-lactams are widely used to treat bacterial infections in humans. In most countries, they are the largest group of antibiotics used by hospitals to treat infections caused by Gram-negative bacteria. Enterobacteriaceae, natural microbiota of the human gastrointestinal tract, represent a large part of bacterial communities colonizing hospital effluents, and they could be a source of genes encoding beta-lactamases and extended-spectrum-beta-lactamases (ESBLs). Those genes may be transmitted to other bacteria present in sewage and the environment. The prevalence of ESBL-producing Enterobacteriaceae was investigated in 63 sewage samples from three hospitals in Olsztyn, Poland. In the group of 310 randomly sampled strains isolated from hospital effluents, 295 (95.2%), 253 (81.6%) and 228 (73.5%) isolates were resistant to cefotaxime, ceftazidime and cefpodoxime, respectively. 150 of them were phenotypically ESBL-positive, but only 91 (29.4%) of those isolates harbored ESBL-genes. In the group of ESBL-producers, 54.9% (50/91), 39.6% (36/91), 24.2% (22/91) and 11.0% (10/91) carried blaCTx-M group 1, blaCTx-M group 9, blaSHV and blaTEM genes, respectively. More than 27.5% (25/91) of the analyzed isolates carried up to three bla genes. High minimum inhibitory concentration (MIC) values of cefotaxime and ceftazidime (≥512 μg/mL) were observed for the studied microorganisms. Escherichia coli and Citrobacter freundii were the most frequently identified ESBL-positive strains. A statistically significant correlation was observed between antibiotics consumption in each hospital and the incidence of ESBL-positive isolates in hospital effluents.
    [Abstract] [Full Text] [Related] [New Search]