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  • Title: Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives.
    Author: Zhou Y, Xu X, Sun Y, Wang H, Sun H, You Q.
    Journal: Bioorg Med Chem Lett; 2013 May 15; 23(10):2974-8. PubMed ID: 23566520.
    Abstract:
    A novel series of amide derivatives of lomefloxacin were synthesized and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against a panel of five human cancer cell lines. Of the compounds prepared compounds 9d and 9g exhibited strong inhibition against topoisomerase II at 100μM. In addition, docking studies were performed to predict the inhibition mode.
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