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  • Title: The FBW7-KLF2 axis regulates endothelial functions.
    Author: Zhao Y, Sun Y.
    Journal: Cell Res; 2013 Jun; 23(6):741-3. PubMed ID: 23567558.
    Abstract:
    FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.
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