These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Association between vascular endothelial growth factor +936 C/T gene polymorphism and age-related macular degeneration.
    Author: Jiang Y, Liang G, Wang L, Jiang J, Du G, Huang Y.
    Journal: J Int Med Res; 2013 Apr; 41(2):317-24. PubMed ID: 23569009.
    Abstract:
    OBJECTIVES: The pathogenesis of age-related macular degeneration (AMD) remains unknown. Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and a target for inhibition therapy in wet AMD. This study investigated the association between the VEGF +936 C/T gene polymorphism and AMD, in a Chinese Han population. METHODS: Patients with AMD, and age- and sex-matched controls were enrolled. Restriction fragment length polymorphism was used to analyse the VEGF +936 polymorphism in the promoter and the 3' untranslated region of the gene. RESULTS: The study included 200 AMD patients and 200 control subjects. There was a significantly higher prevalence of the TT genotype among AMD patients (9.0%) compared with controls (3.5%); the odds ratio for this genotype in AMD patients was 2.73 (95% confidence intervals 1.11, 6.68). There were no significant associations between any genotype and AMD subphenotypic categories (early, geographic atrophy, choroidal neovascularization). CONCLUSIONS: The present study findings suggested that the VEGF +936 TT genotype was associated with AMD among Han Chinese patients.
    [Abstract] [Full Text] [Related] [New Search]