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  • Title: Hyrtimomines A-C, new heteroaromatic alkaloids from a sponge Hyrtios sp.
    Author: Momose R, Tanaka N, Fromont J, Kobayashi J.
    Journal: Org Lett; 2013 Apr 19; 15(8):2010-3. PubMed ID: 23570337.
    Abstract:
    Three new alkaloids, hyrtimomines A-C (1-3), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1-3 were elucidated on the basis of spectroscopic analysis and application of a phenylglycine methyl ester (PGME) method. Hyrtimomines A (1) and B (2) are heteroaromatic alkaloids possessing a fused hexacyclic 6/5/6/6/7/5 ring system, while hyrtimomine C (3) is an alkaloid consisting of hydroxyindole and azepino-hydroxyindole moieties. Hyrtimomine A (1) exhibited cytotoxicity against KB and L1210 cells.
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