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  • Title: Impaired visual recognition memory predicts Alzheimer's disease in amnestic mild cognitive impairment.
    Author: Didic M, Felician O, Barbeau EJ, Mancini J, Latger-Florence C, Tramoni E, Ceccaldi M.
    Journal: Dement Geriatr Cogn Disord; 2013; 35(5-6):291-9. PubMed ID: 23572062.
    Abstract:
    BACKGROUND: In the common form of Alzheimer's disease (AD), neurofibrillary tangles, which are associated with cognitive dysfunction, initially develop in the anterior subhippocampal (perirhinal/entorhinal) cortex before reaching the hippocampus. This area plays a key role in visual recognition memory (VRM). Impaired VRM could therefore be an early marker of AD. METHODS: An extensive neuropsychological assessment including VRM tasks was performed in 26 patients with single-domain amnestic mild cognitive impairment at baseline. We evaluated the diagnostic accuracy of neuropsychological tests using ROC curve analyses in a prospective longitudinal study until conversion to probable AD or with a follow-up of at least 6 years. RESULTS: VRM performance predicted conversion to AD with a sensitivity of 80% and a specificity of 90.9%. Combining the assessment of VRM with a verbal memory task increased diagnostic accuracy. CONCLUSIONS: Cognitive 'biomarkers' evaluating the function of brain areas that are the target of degenerative change should be considered for the early diagnosis of AD.
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