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  • Title: HLA typing in Brazilian boys with aromatic antiepileptic drug-induced DRESS.
    Author: Gaeti WP, Obreli-Neto PR, Moliterno RA, Schiavon GB, Cuman RK.
    Journal: Int J Clin Pharm; 2013 Jun; 35(3):319-22. PubMed ID: 23575622.
    Abstract:
    CASES DESCRIPTION: We report two cases of drug rash with eosinophilia and systemic symptoms (DRESS) associated with the use of carbamazepine and phenytoin in Brazilian boys tested for human leukocyte antigen (HLA) class I and II alleles. The clinical manifestations were similar: a maculopapular eruption progressing to exfoliative erythroderma, fever, and lymphadenopathy. Leukocytosis, atypical lymphocytes, and liver injury were also observed. Assessment of causality using the Naranjo algorithm established a "probable" relationship (score 6) in both cases. Case 1 patient presented the following results of HLA typing: HLA-A*02,29 B*44,50 C*06,16 DRB1*01,07 DQA1*01,02. Case 2 patient presented the following results of HLA typing: HLAA*23,24 B*39,53 C*04,07 DRB1*04,08 DQA1*03,05 DQB1*03,03. CONCLUSION: Neither of the cases reported here presented HLA typing similar to that strongly associated with the occurrence of DRESS in Asian or European patients.
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