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  • Title: Corticotropin-releasing factor (CRF) increases paradoxical sleep (PS) rebound in PS-deprived rats.
    Author: Marrosu F, Gessa GL, Giagheddu M, Fratta W.
    Journal: Brain Res; 1990 May 07; 515(1-2):315-8. PubMed ID: 2357570.
    Abstract:
    The intracerebroventricular injection (1 microgram) of murine corticotropin-releasing factor (r-CRF) to rats after 72 h of sleep deprivation markedly postponed the sleep onset, reduced slow wave sleep and prolonged the duration of paradoxical sleep (PS) episodes. Moreover, CRF is-to our knowledge-the first compound to be able to further prolong PS in a condition (sleep deprivation) in which its duration is already increased. Our findings raise the possibility that CRF might play a physiological role in the regulation of the sleep-wakefulness cycle.
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