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  • Title: Silicone sheet containing all-trans retinoic acid and hydroquinone for the treatment of epidermal melanosis.
    Author: Iida S, Takushima A, Ohura N, Sato S, Kurita M, Harii K.
    Journal: Dermatol Surg; 2013 Aug; 39(8):1237-42. PubMed ID: 23577722.
    Abstract:
    BACKGROUND: Although bleaching treatment using all-trans retinoic acid (RA) and hydroquinone (HQ) improves epidermal melanosis, the application of two medications and the irritant dermatitis induced by RA inconvenience patients. To overcome these problems, we developed a silicone sheet containing RA and HQ. OBJECTIVE: To compare the efficacy of a silicone sheet containing RA and HQ with that of conventional bleaching treatment. METHOD: Silicone sheets containing 1% RA and 5% HQ were applied at night during the bleaching phase of 4 weeks, followed by application of sheets containing 5% HQ during the healing phase of 4 weeks. Hemifacial epidermal melanosis, for which the sheets were applied, was compared with a contralateral face which was treated conventionally using RA and HQ. Twenty-four Japanese women who were enrolled in this study and followed up for more than 6 months were analyzed. RESULTS: RA/HQ sheets improved epidermal melanosis, as did the conventional bleaching method, but irritant dermatitis occurred less in patients treated using silicone sheets. CONCLUSION: RA/HQ sheets, which are easily applied to face skin, can improve epidermal melanosis to the same extent as conventional bleaching.
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