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  • Title: [Expression of amyloid beta-protein in bone tissue of APP/PS1 transgenic mouse].
    Author: Wang TH, Jiang Y, Xiao LP.
    Journal: Zhonghua Yi Xue Za Zhi; 2013 Jan 01; 93(1):65-8. PubMed ID: 23578460.
    Abstract:
    OBJECTIVE: To explore the expression pattern of amyloid beta-protein (Aβ) in bone tissue and elucidate its possible effects on bone metabolism of proximal tibia in APP/PS1 transgenic mouse. METHODS: Immunohistochemistry and immunofluorescence were used to analyze the horizontal and longitudinal sections of proximal tibia in 9-month-old APP/PS1 transgenic mouse. And the tissues of APP/PS1 transgenic and wild-type mice were harvested to analyze the serum levels of tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) by enzyme-linked immunosorbent assay (ELISA). Micro-computed tomography (micro-CT) was used to analyze the changes of bone microarchitecture and bone mineral density (BMD) of proximal tibia. RESULTS: Aβ was expressed in bone trabecular and osteocytes of proximal tibia in APP/PS1 transgenic mouse. As compared with wild-type mice (32.1 ± 6.8; 28.9 ± 4.5; 3.17 ± 0.26; 3.17 ± 0.26; 1229 ± 113), the serum levels of TNF-α (42.3 ± 7.4) and IL-6 (40.9 ± 6.7) of APP/PS1 transgenic mice significantly increased. However bone microarchitecture (1.95 ± 0.22) and BMD (187 ± 29; 1109 ± 104) of proximal tibia were significantly lower on micro-CT (P < 0.05). CONCLUSION: Aβ is expressed in bone tissue and it is associated with the changes of bone mineral density. Thus it may play an important role in the pathogenesis of osteoporosis through the changes of TNF-α and IL-6 in APP/PS1 transgenic mouse.
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