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  • Title: Canine cutaneous histiocytomas are clonal lesions as defined by X-linked clonality testing.
    Author: Delcour NM, Klopfleisch R, Gruber AD, Weiss AT.
    Journal: J Comp Pathol; 2013; 149(2-3):192-8. PubMed ID: 23582639.
    Abstract:
    Canine cutaneous histiocytoma (CCH) is the most common skin tumour of young dogs. CCH is assumed to be a tumour, but as these lesions often undergo complete regression, they have also been proposed to represent hamartomas or unregulated hyperplasia of polyclonal histiocytic cells. To demonstrate a monoclonal origin of CCH, and thereby a probable neoplastic nature, a clonality assay was established based on the heterozygosity of a polymorphic microsatellite within the canine androgen receptor located on the X chromosome. Analysis of 11 histiocytomas identified a non-random X chromosome inactivation of one androgen receptor allele. CCH may, therefore, be a clonal lesion and of neoplastic nature.
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