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  • Title: Efficacy of tigecycline alone and in combination with gentamicin in the treatment of experimental endocarditis due to linezolid-resistant Enterococcus faecium.
    Author: Pontikis K, Pefanis A, Tsaganos T, Tzepi IM, Carrer DP, Giamarellou H.
    Journal: Antimicrob Agents Chemother; 2013 Jul; 57(7):3392-4. PubMed ID: 23587961.
    Abstract:
    We evaluated the efficacy of tigecycline in a rabbit model of experimental endocarditis caused by a linezolid-resistant clinical strain of Enterococcus faecium. Tigecycline-treated animals had a 2.8-log10-CFU/g reduction in microbial counts in excised vegetations compared with controls. Addition of gentamicin caused a further arithmetical reduction in colony counts. The therapeutic effect was sustained 5 days after completion of treatment, as shown by relapse studies performed in treatment groups.
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