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  • Title: Catalytic three-component domino reaction for the preparation of trisubstituted oxazoles.
    Author: Wachenfeldt Hv, Röse P, Paulsen F, Loganathan N, Strand D.
    Journal: Chemistry; 2013 Jun 10; 19(24):7982-8. PubMed ID: 23592540.
    Abstract:
    Multicomponent reactions are attractive for assembling functionalized heterocyclic compounds. To this end, an efficient gold-catalyzed three-component domino reaction to form oxazoles directly from imines, alkynes, and acid chlorides is presented. The reaction proceeds in a single synthetic step by using a gold(III)-N,N'-ethylenebis(salicylimine) (salen) catalyst to give trisubstituted oxazoles in up to 96 % yield. The substrate scope, a mechanistic study exploring the role of the gold catalyst, and the synthetic applications of the oxazole products are discussed.
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