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  • Title: [Successful treatment of a patient with ulcerated necrobiosis lipoidica non diabeticorum with adalimumab].
    Author: Leister L, Körber A, Dissemond J.
    Journal: Hautarzt; 2013 Jul; 64(7):509-11. PubMed ID: 23595890.
    Abstract:
    Necrobiosis lipoidica is a rare inflammatory granulomatous skin disease of unknown etiology which is associated with diabetes mellitus in about 60 % of the patients. In up to 30 % of these patients extremely painful and often hard-to-heal ulcerations occur in the course of the disease. We present a new therapeutic option using adalimumab to treat refractory ulcerated necrobiosis lipoidica non diabeticorum. The clinical efficacy of adalimumab probably reflects an immunomodulatory effect through the specific TNF-α inhibition which is one central aspect of the underlying inflammation. Thus, adalimumab could represent promising new treatment option, especially for patients with otherwise therapy-refractory ulcerated necrobiosis lipoidica.
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