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  • Title: Size matters, so does shape: Inhibition of transcription of T7 RNA polymerase by iron(II) clathrochelates.
    Author: Novikov VV, Varzatskii OA, Negrutska VV, Bubnov YN, Palchykovska LG, Dubey IY, Voloshin YZ.
    Journal: J Inorg Biochem; 2013 Jul; 124():42-5. PubMed ID: 23598064.
    Abstract:
    Coordination and organoelement compounds are rarely proposed as the drug candidates despite their vast potential in the area owing to their strictly controlled geometry and rather extensive surface. This is the first example of the inhibition of transcription in the system of T7 RNA polymerase by cage metal complexes. Their IC50 values reach as low as the nanomolar range, placing them among the most potent metal-based transcription inhibitors.
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