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  • Title: The discovery of colchicine-SAHA hybrids as a new class of antitumor agents.
    Author: Zhang X, Zhang J, Tong L, Luo Y, Su M, Zang Y, Li J, Lu W, Chen Y.
    Journal: Bioorg Med Chem; 2013 Jun 01; 21(11):3240-4. PubMed ID: 23602523.
    Abstract:
    A novel class of colchicine-SAHA hybrids were designed and synthesised based on the synergistic antitumor effect of tubulin inhibitors and histone deacetylases (HDAC) inhibitors. To the best of our knowledge, this is the first design of molecules that are dual inhibitors of tubulin and HDAC. Biological evaluations of these compounds included the inhibitory activity of HDAC, in vitro cell cycle analysis in BEL-7402 cells as well as cytotoxicity in five cancer cell lines.
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