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  • Title: Selenium utilization in humans--a long-term, self-labeling experiment with stable isotopes.
    Author: Veillon C, Patterson KY, Button LN, Sytkowski AJ.
    Journal: Am J Clin Nutr; 1990 Jul; 52(1):155-8. PubMed ID: 2360544.
    Abstract:
    A stable (nonradioactive) isotope of selenium in a chemical form common in foods (selenomethionine) or inorganic selenite was taken orally (200 micrograms/d) for 3 wk to label deep body pools. By deep body pools we mean selenium compartments that are large and/or have a slow turnover (exchange) rate. Blood plasma was removed, stored for 11 mo, and later reinfused as a labeled tracer dose with the selenium label in all of the biologically significant chemical forms. Accessible tissues such as red blood cells were highly labeled (20-25%) in the subjects receiving selenomethionine. Selenium from deep body pools is excreted primarily via the urine (80%). Reexcretion of previously absorbed selenium back into the gastrointestinal tract can be measured, avoiding a major source of error in conventional balance studies used to estimate nutrient absorption.
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