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  • Title: Intracellular pathogen detection by RIG-I-like receptors.
    Author: Dixit E, Kagan JC.
    Journal: Adv Immunol; 2013; 117():99-125. PubMed ID: 23611287.
    Abstract:
    The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA and thus responsible for intracellular immune surveillance against infection. RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatory cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction.
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