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  • Title: New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties.
    Author: Panda SS, Jain SC.
    Journal: Bioorg Med Chem Lett; 2013 Jun 01; 23(11):3225-9. PubMed ID: 23611733.
    Abstract:
    A series of quinolone derivatives, containing different heterocyclic amines were prepared. Synthesized compounds were evaluated for their in vitro antimicrobial activities against two Gram-positive bacteria, three Gram-negative bacteria as well as four fungi. All the derivatives showed good activity towards Gram-positive bacteria and less activity towards Gram-negative bacteria. They also showed moderate to comparable activity against Aspergillus niger and Candida albicans and low to moderate antifungal activity against Aspergillus fumigatus and Aspergillus flavus.
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