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  • Title: A review of the pathogenesis of adult peritonsillar abscess: time for a re-evaluation.
    Author: Powell EL, Powell J, Samuel JR, Wilson JA.
    Journal: J Antimicrob Chemother; 2013 Sep; 68(9):1941-50. PubMed ID: 23612569.
    Abstract:
    OBJECTIVES: To perform a multifactorial exploration of the aetiology of peritonsillar abscess (PTA) in adults, in order to develop greater clinical understanding of the condition and improve management. DESIGN: A literature review exploring key pathogens, predisposing host factors and current pathogenic hypotheses. METHODS: A PubMed search for articles published between January 1980 and January 2012 using the terms 'peritonsillar abscess AND microbiology', 'peritonsillar abscess AND pathophysiology' and 'peritonsillar abscess AND etiology'. RESULTS: Major pathogens in PTA are opportunistic microflora. Group A streptococcal PTA infections present differently from polymicrobial PTA. A number of host factors influence the conditions required for the pathogenesis of PTA. CONCLUSIONS: PTA is clinically distinct from acute tonsillitis and occurs in people with a chronic underlying susceptibility. Targeting host factors, including oral hygiene, antibiotic use and smoking, may prevent PTA. Re-education of clinicians concerning the aetiology of PTA is necessary for appropriate disease management.
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