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  • Title: The use of amniotic fluid discordance in the early second trimester to predict severe twin-twin transfusion syndrome.
    Author: Yamamoto R, Ishii K, Muto H, Kawaguchi H, Murata M, Hayashi S, Matsushita M, Murakoshi T, Mitsuda N.
    Journal: Fetal Diagn Ther; 2013; 34(1):8-12. PubMed ID: 23615462.
    Abstract:
    INTRODUCTION: The appropriate effectiveness of inter-twin amniotic fluid discordance (AFD) in the early second trimester for the prediction of severe twin-twin transfusion syndrome (TTTS) was evaluated. MATERIALS AND METHODS: The largest AFD between 16 and 18 weeks' gestation was analyzed in correlation with TTTS development defined by polyhydramnios with a maximum vertical pocket (MVP) ≥8 cm combined with oligohydramnios with a MVP ≤2 cm using the receiver operating characteristics curve. All pregnancies were stratified according to an AFD cutoff, and perinatal outcomes were compared between two groups. RESULTS: A total of 223 twin monochorionic pregnancies met the inclusion criteria and 20 patients (8.9%) developed TTTS. An AFD ≥4 cm was calculated to be the optimal point of demarcation to predict subsequent TTTS. The sensitivity and specificity of this AFD cutoff for the development of TTTS were 70 and 97%, respectively. An AFD ≥4 cm was associated with a significantly increased risk of the development of TTTS (70 vs. 2.9%; p < 0.01). Those pregnancies with AFD tended to deliver at an earlier gestational age and were also significantly associated with intrauterine fetal deaths. DISCUSSION: The AFD between monochorionic diamniotic twins in the early second trimester may be useful for the prediction of severe TTTS development.
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